Label: VARDENAFIL HYDROCHLORIDE tablet

Levitra® (vardenafil) is an oral medication for ED that starts working in about 60 minutes and lasts up to five hours.

Renal Dose Adjustments

The total time to 1 mm or greater ST-segment depression was similar to placebo in both the 10 mg and the 20 mg vardenafil groups (10 mg LEVITRA vs. placebo: 380±108 and 334±108 seconds; 20 mg vardenafil vs. placebo: 364±101 and 366±105 seconds, respectively). Single oral doses of phosphodiesterase inhibitors have demonstrated transient dose- related impairment of color discrimination (blue/green) using the Farnsworth-Munsell 100-hue test and reductions in electroretinogram (ERG) b-wave amplitudes, with peak fildena ct effects near the time of peak plasma levels. In a single dose study in 25 normal males, vardenafil 40 mg, twice the maximum daily recommended dose, did not alter visual acuity, intraocular pressure, fundoscopic and slit lamp findings.

Usual Geriatric Dose for:

In another double blind, placebo controlled clinical trial, at least 15 doses of 20 mg vardenafil were administered over 8 weeks versus placebo to 52 males. There was no effect on sperm motility or morphology after single 20 mg oral doses of vardenafil in healthy volunteers. Absorption: Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%. Two food-effect studies were conducted which showed that high-fat meals caused a reduction in Cmax by 18%-50%. Distribution: The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution.

Biochem/physiol Actions

Metabolism: Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. Elimination: The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours. Pediatrics: Vardenafil is not indicated for use in pediatric patients. Geriatric: In a healthy volunteer study of elderly males (≥65 years) and younger males (18-45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males. Hepatic Impairment: In volunteers with mild hepatic impairment (Child-Pugh A), the Cmax and AUC following a 10 mg vardenafil dose were increased by 22% and 17%, respectively, compared to healthy control subjects. Levitra® is a brand-name medication that contains the active ingredient vardenafil, which is used to treat erectile dysfunction (ED) by increasing blood flow to the penis during sexual stimulation.

• Vardenafil 10mg can improve confidence and sexual satisfaction.
• Use it responsibly to avoid dependency or misusage.
• Discuss any allergies to medications with your healthcare provider.
• Always follow the prescribed regimen for optimal results.
• It’s important to inform your doctor about any recent surgeries or health issues.
• Certain foods and beverages may affect the medication’s effectiveness.
• Vardenafil should not be used in combination with recreational drugs.
• Notify your doctor if you experience persistent pain or erection.
• Be aware of potential vision changes, including blurred or blue-tinted vision.
• Store medication safely to prevent accidental ingestion by children.

Vardenafil works the same way as Levitra and has the same benefits and risks, per the FDA.

This medication belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors and works similarly to sildenafil (Viagra®) and tadalafil (Cialis®). Vardenafil is typically taken as needed, about 60 minutes before sexual activity, and its effects can last up to five hours.

• Vardenafil 10mg should be used only under medical supervision.
• Overdose may cause serious side effects like priapism or sudden vision loss.
• The medication is available by prescription and not for recreational use.
• Male patients with heart issues should consult a doctor before use.
• Vardenafil may interact with other medications like antibiotics or antifungals.
• Alcohol consumption can increase the risk of side effects when taking vardenafil.
• It’s important to follow the prescribed dosage strictly for safety.
• Use caution if you have liver or kidney problems while taking vardenafil.
• Women and children should avoid using vardenafil, as it's designed for men.
• Discuss all health conditions and medications with your healthcare provider first.

Common side effects include headaches, flushing, nasal congestion, and dizziness. People with cardiovascular conditions and those taking nitrates should use caution with this drug.

5.12 Sexually Transmitted Disease

In volunteers with moderate hepatic impairment (Child- Pugh B), the Cmax and AUC following a 10 mg vardenafil dose were increased by 130% and 160%, respectively, compared to healthy control subjects. Renal Impairment: In male volunteers with ClCr= 50-80 mL/min, the pharmacokinetics of vardenafil were similar to those observed in a control group with ClCr >80 mL/min. In male volunteers with ClCr = 30-50 mL/min or ClCr <30 mL/min renal impairment groups, the AUC of vardenafil was 20-30% higher compared to that observed in a control group with ClCr >80 mL/min). Advise patients sex with tablet of the contraindication of vardenafil with regular and/or intermittent use of organic nitrates. Patients should be counseled that concomitant use of vardenafil with nitrates could cause blood pressure to suddenly drop to an unsafe level, resulting in dizziness, syncope, or even heart attack or stroke.

What are the most common side effects of vardenafil?

Inform patients of the potential cardiac risk of sexual activity for patients with preexisting cardiovascular risk factors. Inform patients that in some patients concomitant use of PDE5 inhibitors, including vardenafil, with alpha-blockers can lower blood pressure significantly leading to symptomatic hypotension (for example, fainting). Patients prescribed vardenafil who are taking alpha-blockers should be started on the lowest recommended starting dose. Patients should be advised to contact the prescribing physician if other anti-hypertensive drugs or new medications that may interact with vardenafil are prescribed by another healthcare provider. Discuss with patients the appropriate use of vardenafil and its anticipated benefits.

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It should be explained that sexual stimulation is required for an erection to occur after taking vardenafil. It should be taken approximately 60 minutes before sexual activity. Patients should be counseled regarding the dosing of vardenafil especially regarding the maximum daily dose. Patients should be advised to contact their healthcare provider for dose modification if they are not satisfied with the quality of their sexual performance with vardenafil or in the case of an unwanted effect. Inform patients that there have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for vardenafil and this class of compounds. Vardenafil hydrochloride tablets are indicated to treat: Most common adverse reactions reported (≥2% of patients) are: Levitra® is no longer available on the market, but its generic, vardenafil, is.

The cost of generic Levitra may vary depending on factors such as your insurance plan, the dosage, quantity, and where you buy it. Without insurance, the average cost of generic Levitra is between $500 and $1,400 for a 30-day supply.

How To Get Vardenafil

The use of vardenafil offers no protection against sexually transmitted diseases. Counseling of patients about protective measure necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), should be considered. Advise patients that the disintegrating tablet (Staxyn) is not interchangeable with the film-coated tablet (Levitra). General Notes: May be taken with or without food. (Tablet) Place on tongue to disintegrate; take without liquid and immediately upon removal from blister. However, coupons or discount cards may be available to bring down the price.

What side effects can this medication cause?

Advise patients to stop treatment and seek medical attention in the event of sudden loss of vision in one or both eyes. It is not possible to fildena super active 100 determine whether these events were related directly to the use of PDE5 inhibitors or to other factors. Inform patients of the increased risk of NAION in individuals who have already experienced NAION in one eye and discuss the increased risk of NAION among the general population in patients with a "crowded" optic disc, although evidence is insufficient to support screening of prospective users of PDE5 inhibitor, including vardenafil, for this uncommon condition. Advise patients to stop treatment and seek prompt medical attention in the event of sudden decrease or loss of hearing. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Some insurance companies may not cover the cost of generic Levitra if they don’t consider it medically necessary. Administration with nitrates and nitric oxide donors Administration with nitrates and nitric oxide donors Administration with guanylate cyclase (GC) stimulators, such as riociguat Administration with guanylate cyclase (GC) stimulators, such as riociguat Cardiovascular effects: Patients should not use vardenafil hydrochloride if sex is inadvisable due to cardiovascular status Cardiovascular effects: Patients should not use vardenafil hydrochloride if sex is inadvisable due to cardiovascular status Risk of prolonged erection: In the event that an erection lasts more than 4 hours, the patient should seek immediate medical assistance Risk of prolonged erection: In the event that an erection lasts more than 4 hours, the patient should seek immediate medical assistance Effects on the eye: Patients should stop use of vardenafil hydrochloride and seek medical attention in the event of sudden loss of vision in one or both eyes, which could be a sign of nonarteritic anterior ischemic optic neuropathy (NAION) Effects on the eye: Patients should stop use of vardenafil hydrochloride and seek medical attention in the event of sudden loss of vision in one or both eyes, which could be a sign of nonarteritic anterior ischemic optic neuropathy (NAION) Sudden hearing loss: Patients should stop vardenafil hydrochloride and seek medical attention in the event of sudden decrease or loss in hearing Sudden hearing loss: Patients should stop vardenafil hydrochloride and seek medical attention in the event of sudden decrease or loss in hearing Alpha-blockers: Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers Alpha-blockers: Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers QT prolongation: Patients with congenital QT syndrome or taking class IA or III antiarrhythmics should avoid using vardenafil hydrochloride QT prolongation: Patients with congenital QT syndrome or taking class IA or III antiarrhythmics should avoid using vardenafil hydrochloride The typical generic Levitra dose is 10 mg, but the medication is also available in 2.5 mg, 5 mg, and 20 mg doses.

What is the most important information I should know about vardenafil?

The 80 mg dose of vardenafil (four times the highest recommended dose) was chosen because this dose yields plasma concentrations covering those observed upon co-administration of a low-dose of vardenafil (5 mg) and 600 mg BID of ritonavir. In this study, the mean increase in heart rate associated with a 10 mg dose of vardenafil compared to placebo was 5 beats/minute and with an 80 mg dose the mean increase was 6 beats/minute. Therapeutic and supratherapeutic doses of vardenafil and the active control moxifloxacin produced similar increases in QTc interval. The clinical impact of these QTc changes is unknown. In a separate post-marketing study of 44 healthy volunteers, single doses of 10 mg vardenafil resulted in a placebo-subtracted mean change from baseline of QTcF (Fridericia correction) of 5 msec (90% CI: 2,8).

General adverse events

Single doses of gatifloxacin 400 mg resulted in a placebo-subtracted mean change from baseline QTcF of 4 msec (90% CI: 1,7). When vardenafil 10 mg and gatifloxacin 400 mg were co-administered, the mean QTcF change from baseline was additive when compared to either drug alone and produced a mean QTcF change of 9 msec from baseline (90% CI: 6,11). The clinical impact of these QT changes is unknown. The patient population included men aged 40-80 years with stable exercise- induced angina documented by at least one of the following: 1) prior history of myocardial infarction (MI), coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA), or stenting (not within 6 months); 2) positive coronary angiogram showing at least 60% narrowing of the diameter of at least one major coronary artery; or 3) a positive stress echocardiogram or stress nuclear perfusion study. Results of these studies showed that vardenafil did not alter the total treadmill exercise time compared to placebo (10 mg vardenafil vs.

Average Pharmacy Cost for VARDENAFIL HCL

placebo: 433±109 and 426±105 seconds, respectively; 20 mg vardenafil vs. placebo: 414±114 and 411±124 seconds, respectively). The total time to angina was not altered by vardenafil when compared to placebo (10 mg vardenafil vs. placebo: 291±123 and 292±110 seconds; 20 mg vardenafil vs. placebo: 354±137 and 347±143 seconds, respectively).